Lack of sleep and excessive stimulation – work, hectic pace, worry – can manifest in a state of “turbo-charged wakefulness” while at the same time being bone tired.
Coined by clinical psychologist Rubin Naiman, being “wired but tired” or t’wired is characterized by “racing brain waves, a rapid heart rate, overheated core body temperature and dysfunctional hormonal rhythms… all of which serve to hinder night time sleep and mask daytime sleepiness.”
The t’wired cycle disrupts and exhausts the delicate balance of steroid hormones that are produced by the adrenal glands, including cortisol and adrenaline , testosterone and estrogen, vitamin D and the raw material that they are all made from, namely cholesterol. Normally, when a stressor is perceived, the hypothalamus signals the pituitary gland which in turn triggers the adrenals to release these hormones to turbocharge the body for fight or flight. When stress is chronic, however, the hypothalamic-pituitary-adrenal (HPA) axis becomes dysregulated and adrenal fatigue can occur. Chronically elevated cortisol levels can also disturb the immune and inflammatory response.
The book Magnesium in the Central Nervous System (2011) reviews research on the role of magnesium in helping to modulate this neuroendocrine response in mammals. By modifying stress reactions, magnesium, B vitamins and other nutrients help regulate adrenal hormones and promote homeostasis.
Endocrine System & Steroid Pathway
Vitamins – Common 30
Minerals – Common 30