The DETOX LIVER PATHWAYS #2 expands on the list of potential stressors found in our first Detox Liver kit. This follow-up kit focuses on main detoxification pathways in Phase I and Phase II but also includes signatures of specific nosodes and sarcodes. Useful, short descriptions, most with external links to more info, are included online next to the individual vials in this new kit.
_____________
The liver is the second largest organ in the human body (next to integumentary) and performs over 300 functions. Its primary functions are:
- Bile production and excretion.
- Excretion of bilirubin, cholesterol, hormones, and drugs.
- Metabolism of fats, proteins, and carbohydrates.
- Enzyme activation.
- Storage of glycogen, vitamins, and minerals.
- Synthesis of plasma proteins, such as albumin, and clotting factors.
The two main pathways for detoxification in the liver are called Phase I and Phase II.
“Phase I enzymes modify fat-soluble toxins via certain chemical reactions. Among these are oxidation, reduction, and hydrolysis. These reactions are what add or expose a place on the toxin for Phase II enzymes...”
Phase 1 reactions that use the cytochrome P450 enzymes, produce free radicals.[2] Phase 2 liver detoxification neutralizes the byproducts of Phase I and other remaining toxins. This phase helps make the toxins less reactive, more water-soluble and easier to excrete.
“Phase 2 detox is known as the conjugation pathway, whereby the liver attaches another molecule to the “intermediate toxin” to render is less harmful. There are 6 types of conjugation that takes place in this phase: sulfation, glucuronidation, glutathione conjugation, methylation, acetylation, and glycination.”
RELATED KITS